Trimethadione, Oral

What are other names for this medicine?

Type of medicine: dione antiseizure

Generic and brand names: trimethadione, oral; Tridione

What is this medicine used for?

This medicine is taken by mouth to control and reduce petit mal epilepsy seizures.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• eye disease
• kidney or liver disease
• lupus
• myasthenia gravis

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your health care provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your health care provider right away. Do not breast-feed while taking this medicine.

How do I take it?

This medicine comes in several forms. If you have the capsules, swallow them whole.

Tablets may be swallowed, chewed, or crushed and mixed with water.

Do not stop taking this medicine without your healthcare provider's approval, even if you feel better.

If you have stomach upset while taking this medicine, try taking it with food.

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as directed every day in regularly scheduled doses.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

Symptoms of an acute overdose have not been reported.

What should I watch out for?

Your healthcare provider will want to see you regularly to check how this medicine affects you. Keep all your appointments.

This medicine may make your eyes more sensitive to light. Wearing dark glasses outdoors will help lessen your discomfort. Also, you may sunburn more easily than usual. Wear sunscreen lotions and protective clothing when you are outdoors.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take depressant drugs unless your healthcare provider approves.

This medicine may make you drowsy. Do not drive or operate machinery unless you are fully alert.

Carry some form of ID that states that you have seizures and are taking this medicine. Tell all healthcare providers and dentists who treat you that you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Serious (report these to your healthcare provider right away): Vision changes; severe drowsiness or dizziness; unusual bleeding or bruising; rash; yellow skin or eyes; trouble urinating; blood in the urine; sore throat, fever, or other signs of infection.

Other: Irritability, headache, tiredness, nausea, vomiting, stomach pain, loss of appetite.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• alcohol
• antidepressants such as amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), and doxepin (Sinequan)
• barbiturates such as phenobarbital, butabarbital (Butisol), and pentobarbital (Nembutal)
• isoniazid
• narcotic pain medicines such as codeine, morphine, meperidine (Demerol), hydromorphone (Dilaudid), and oxycodone (Roxicodone, OxyContin)
• sedatives such as flurazepam (Dalmane), estazolam (ProSom), and temazepam (Restoril)

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

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