Temsirolimus, Infusion

What are other names for this medicine?

Type of medicine: antineoplastic (anticancer); kinase inhibitor

Generic and brand names: temsirolimus, infusion; Torisel

What is this medicine used for?

This medicine is used to treat advanced renal cell carcinoma (kidney cancer).

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• a blood or bone marrow disorder
• diabetes
• high cholesterol or triglycerides
• liver or kidney disease

Also tell your provider if you have any kind of infection or if you are scheduled to have any kind of surgery in the near future.

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine and for at least 3 months after treatment has stopped. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.

How do I use it?

Infusions of this medicine are given by your healthcare provider.

What should I watch out for?

You may get infections more easily when you are taking this medicine. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

This medicine may cause bleeding in the brain, bleeding in the bowels, and slow wound healing.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

You may lose your hair during this treatment. Your hair will grow back when you stop taking this medicine.

Men should use effective birth control during treatment and for at least 3 months after the last dose because this medicine may affect the sperm and lead to birth defects.

This medicine may increase the risk of developing diabetes. If you have diabetes, this medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider before you change your diet or dosage of diabetes medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Fever, chills, cough, shortness of breath, chest pain, unusual bleeding or bruising, yellowing of your skin or eyes, black tarry stools, increased thirst, increased urination, stomach pain, mouth sores, blood in your urine, painful urination.

Other: Dizziness, confusion, unexplained swelling, joint pain, hair loss, rash, nausea, vomiting, diarrhea, sore throat, loss of appetite, headache.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• antibiotics such as clarithromycin (Biaxin) and telithromycin (Ketek)
• antifungal medicines such as itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (VFEND)
• anti-HIV medicines such as amprenavir (Agenerase), atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), delavirdine (Rescriptor), ritonavir (Norvir), and saquinavir (Fortovase, Invirase)
• antiseizure medicines such as carbamazepine (Tegretol, Carbatrol), phenytoin, and phenobarbital
• herbs such as angelica, anise, arnica, asafoetida, capsicum, celery, chamomile, clove, fenugreek, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, horseradish, licorice, onion, papain, passionflower, red clover, St. John's wort, turmeric, and willow
• live vaccines
• medicines that affect blood clotting such as aspirin, heparin, ticlopidine (Ticlid), enoxaparin (Lovenox), dalteparin (Fragmin), clopidogrel (Plavix), and warfarin (Coumadin)
• other medicines to treat cancer such as methotrexate, asparaginase (Elspar), busulfan (Myleran), trastuzumab (Herceptin), and doxorubicin (Rubex, Adriamycin)
• rifabutin (Mycobutin)
• rifampin (Rifadin, Rimactane)
• sunitinib (Sutent)

Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit affects the way this medicine works and may increase the risk of side effects.

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

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This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicines in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

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