Thiothixene, Oral

What are other names for this medicine?

Type of medicine: antipsychotic; phenothiazine

Generic and brand names: thiothixene, oral; Navane

What is this medicine used for?

This medicine is used to treat symptoms of schizophrenia. It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• a blood disease
• breast cancer
• glaucoma
• heart problems
• liver or kidney disease
• Parkinson's disease
• seizures
• trouble urinating or an enlarged prostate

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Take this medicine with food or a full glass of milk or water to lessen stomach upset.

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or take it more often than prescribed. Do not stop taking this medicine without your healthcare provider's approval.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: dizziness, lightheadedness, fainting, tremor, muscle stiffness, drowsiness, irregular heartbeat.

What should I watch out for?

Older adults with dementia are at greater risk for side effects. Talk with your provider about this.

Your healthcare provider may want to check your progress regularly. Do not stop taking this medicine without your healthcare provider's approval. You may need to gradually reduce the dose.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

You may feel dizzy or faint when you get up quickly from sitting or lying down. Getting up slowly may lessen this reaction.

This medicine may make you drowsy. Do not drive or operate machinery unless you are fully alert.

Using this medicine for a long time may cause muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your healthcare provider about this.

While taking this medicine, be careful when you exercise, especially when it is hot. This medicine affects your body's ability to cool down, and you may get too hot. If you get too hot, you might vomit, feel dizzy, have a fast heartbeat, get very stiff muscles, or be confused. Contact your provider right away if you have these symptoms.

This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

This medicine may cause dry mouth. Sucking hard candy, taking sips of water, or chewing sugarless gum may help. Check with your healthcare provider or dentist if this problem does not go away or becomes severe.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Seizures; trouble urinating; yellowing of skin or eyes; unusual weakness or tiredness; fast heartbeat; unexplained fever; muscle stiffness or twitching; uncontrollable tongue or chewing movements; loss of coordination; changes in vision; severe confusion; trouble speaking or swallowing; hot, dry skin or lack of sweating.

Other: Dry mouth, dizziness, drowsiness, trouble sleeping, constipation, weight gain, change in sexual ability or desire, breast enlargement.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• ACE inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace)
• alpha blockers such as prazosin (Minipress) and doxazosin (Cardura)
• angiotensin receptor II blockers such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan)
• antianxiety medicines such as clonazepam (Klonopin), alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam (Serax)
• antibiotics such as ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), and rifampin (Rifadin, Rimactane)
• anticholinergic medicines such as benztropine (Cogentin), dicyclomine (Bentyl), atropine sulfate, belladonna, propantheline (Pro-Banthine), methscopolamine (Pamine), l-hyoscyamine (Levsin, Levsinex), and trihexyphenidyl (Artane)
• antidepressants such as trazodone (Desyrel), amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), doxepin (Sinequan), and maprotiline (Ludiomil)
• antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), clemastine (Tavist), brompheniramine (Dimetane), and dexchlorpheniramine (Polaramine)
• antiseizure medicines such as carbamazepine (Tegretol), phenytoin (Dilantin), primidone (Mysoline), and valproic acid (Depakote, Depakene)
• barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), and phenobarbital
• beta blockers such as atenolol (Tenormin), acebutolol (Sectral), pindolol, metoprolol (Lopressor, Toprol XL), sotalol (Betapace), nadolol (Corgard), propranolol (Inderal), labetalol (Normodyne, Trandate), and carvedilol (Coreg)
• calcium channel blockers such as nifedipine (Adalat, Procardia), isradipine (DynaCirc), felodipine (Plendil), verapamil (Calan, Isoptin), diltiazem (Cardizem), and nicardipine (Cardene)
• heart medicines such as amiodarone (Cordarone, Pacerone), sotalol (Betapace), procainamide, disopyramide (Norpace), flecainide (Tambocor), propafenone (Rythmol), and quinidine
• herbs with sedative effects such as calendula, California poppy, catnip, capsicum, Siberian ginseng, German chamomile, goldenseal, gotu kola, kava, lemon balm, sage, sassafras, stinging nettle, St. John's wort, and valerian
• lithium (Eskalith, Lithobid)
• medicines to treat Parkinson's disease such as apomorphine (Apokyn), bromocriptine (Parlodel), pergolide (Permax), pramipexole (Mirapex), ropinirole (Requip), cabergoline (Dostinex), entacapone (Comtan), and levodopa/carbidopa (Sinemet)
• metoclopramide (Reglan)
• muscle relaxants such as carisoprodol (Soma), chlorzoxazone (Parafon Forte), cyclobenzaprine (Flexeril), metaxalone (Skelaxin), orphenadrine (Norflex), tizanidine (Zanaflex), and methocarbamol (Robaxin)
• narcotic analgesics (painkillers) such as codeine, hydrocodone/acetaminophen (Vicodin, Lortab), oxycodone/acetaminophen (Percocet, Tylox), oxycodone (OxyContin), propoxyphene (Darvocet N-100), meperidine (Demerol), fentanyl (Duragesic, Actiq), and morphine (MS Contin, Oramorph SR, Roxanol)
• other antipsychotic medicines such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine, trifluoperazine (Stelazine), thioridazine, clozapine (Clozaril), risperidone (Risperdal), haloperidol (Haldol), and olanzapine (Zyprexa)
• sleeping pills such as zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), triazolam (Halcion), temazepam (Restoril), and flurazepam (Dalmane)

Do not drink alcohol while you are taking this medicine without your healthcare provider's approval.

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from high humidity and bright light. Store the liquid in the refrigerator. Do not let it freeze.

____________________________________________________

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

Developed by RelayHealth
Published by RelayHealth.
© 2009 RelayHealth and/or its affiliates. All Rights Reserved.